Abstract: Chloroquine was administered to albino rats in the diet for 32 weeks at levels estimated to provide daily intakes of 1.9, 5.6, or 16.8 mg/kg. At the conclusion of the experiment the amount of drug retained in the tissues analyzed ranged from 28 to 37% of the intake for 1 day, and the order of increasing tissue concentrations was: muscle, eye, heart, liver = lung, kidney, and spleen. Hydroxychloroquine was similarly administered to albino rats for 30 weeks at levels estimated to provide daily intakes of 7.8, 19.4, or 48.4 mg/kg. At the conclusion of the experiment the amount of HCQ retained in the tissues ranged from 22 to 31% of the intake for 1 day and the order of increasing concentrations was generally: muscle, eye, heart, kidney, liver, lung, spleen. Chloroquine and desethylchloroquine were administered to albino and pigmented rats (by stomach tube) at a dosage of 40 mg/kg/day of base, 6 days per week for one month. Twenty-four hours after the last dose these animals also retained in the tissues analyzed amounts of these drugs equivalent to about 33% of one daily dose. The order of increasing tissue concentration of CQ in both strains at this time was essentially the same as previously reported (McChesney et al., 1965) except for a reversal of the positions of liver and lung. The order of increasing tissue concentration of desethylchloroquine in both strains was much the same as for chloroquine; i.e., in the albinos it was muscle, eye, heart, kidney, lung, liver = spleen; while in the pigmented rats it was muscle, heart, kidney, lung = liver, spleen, eye. The decrease in tissue concentrations of chloroquine following discontinuance of medication indicated a half-life of 1.5 days, while the corresponding data for desethylchloroquine indicated a half-life of 2.3 days. Tissue concentrations of both of these drugs were generally higher in the females than in the males, but in the case of chloroquine the difference was much more marked.

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   |texte=   Tissue distribution of chloroquine, hydroxychloroquine, and desethylchloroquine in the rat
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